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Development and Validation of a Symptom-Focused Quality of Life Questionnaire (KOQUSS-40) for Gastric Cancer Patients after Gastrectomy

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Abstract
Purpose Patients who have undergone gastrectomy have unique symptoms that are not appropriately assessed using currently avail-able tools. This study developed and validated a symptom-focused quality of life (QoL) questionnaire for patients who have received gastrectomy for gastric cancer. Materials and Methods Based on a literature review, patient interviews, and expert consultation by the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS), the initial item pool was developed. Two large-scale developmental studies were then sequentially conducted for exploratory factor analyses for content validity and item reduction. The final item pool was validated in a separate cohort of patients and assessed for internal consistency, test-retest reliability, construct validity, and clinical validity. Results The initial questionnaire consisted of 46-items in 12 domains. Data from 465 patients at 11 institutions, followed by 499 patients at 13 institutions, were used to conduct item reduction and exploratory factor analyses. The final questionnaire (KOQUSS-40) comprised 40 items within 11 domains. Validation of KOQUSS-40 was conducted on 413 patients from 12 hospitals. KOQUSS-40 was found to have good model fit. The mean summary score of the KOQUSS-40 was correlated with the EORTC QLQ-C30 and STO22 (correlation coefficients, 0.821 and 0.778, respectively). The KOQUSS-40 score was also correlated with clinical factors, and had acceptable internal consistency (> 0.7). Test-retest reliability was greater than 0.8. Conclusion The KOQUSS-40 can be used to assess QoL of gastric cancer patients after gastrectomy and allows for a robust compari-son of surgical techniques in clinical trials.
Author(s)
공성호권오경김성근김아영김영우김창현김형일류근원민재석박기범박종민박지연박지호서병조서윤석손명원손영길송금종신동우안상훈안지영안혜성양한광엄병울유문원윤홍만이솔이예섭이인섭이중엽이혁준인해진정상호허훈
Issued Date
2021
Type
Article
Keyword
Stomach neoplasmsQuality of lifeSurveys and questionnairesValidation study
DOI
10.4143/crt.2020.1270
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8525
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9844204&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Development%20and%20Validation%20of%20a%20Symptom-Focused%20Quality%20of%20Life%20Questionnaire%20(KOQUSS-40)%20for%20Gastric%20Cancer%20Patients%20after%20Gastrectomy&offset=0
Publisher
CANCER RESEARCH AND TREATMENT
Location
대한민국
Language
한국어
ISSN
1598-2998
Citation Volume
53
Citation Number
3
Citation Start Page
763
Citation End Page
772
Appears in Collections:
Medicine > Medicine
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