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Post-resection prognosis of patients with hepatic epithelioid hemangioendothelioma

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Abstract
Purpose: Epithelioid hemangioendothelioma (EHE) is a rare borderline vascular tumor. This retrospective, single-center study evaluated the outcomes of hepatic resection (HR) in patients with hepatic EHE.

Methods: Over the 10-year period from 2009 to 2018, 11 patients with hepatic EHE underwent HR, accounting for 0.1% of the 11,979 adults who underwent HR at our center. Diagnosis of hepatic EHE was confirmed by immunohistochemical staining for CD34, CD31, and factor VIII-related antigen. Results: The 11 patients included 9 females (81.8%) and 2 males (18.2%) with mean age of 43.5 +/- 13.6 years. Preoperative imaging resulted in a preliminary diagnosis of suspected liver metastasis or EHE, with 9 patients (81.8%) undergoing liver biopsy. No patient presented with abnormally elevated concentrations of liver tumor markers. The extents of HR were determined by tumor size and location from trisectionectomy to partial hepatectomy. All patients recovered uneventfully from HR. Five patients showed tumor recurrence, with 4 receiving locoregional treatments for recurrent lesions. The 1-, 3 -and 5-year disease-free survival rates were 90.9%, 54.5%, and 54.5%, respectively. Currently, all patients remain alive and are doing well. Univariate analysis on tumor recurrence showed that tumor size >_ 4 cm was significantly associated with tumor recurrence (P = 0.032), but tumor number >_ 4 was not related to (P = 0.24).

Conclusion: Hepatic EHE is a rare form of primary liver tumor often misdiagnosed as a metastatic tumor. Because of its malignant potential, HR is indicated if possible. HR plus, when necessary, treatment of recurrence yields favorable overall survival rates in patients with hepatic EHE.

[Ann Surg Treat Res 2021;100(3):137-143]
Author(s)
김기훈문덕복송기원안철수이승규정동환하태용홍승모황신
Issued Date
2021
Type
Article
Keyword
CD31 antigenCD34 antigenHemangioendotheliomaHemangiomaOriginalVascular tissue neopla는일반외과학
DOI
10.4174/astr.2021.100.3.137
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8530
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9747403&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Post-resection%20prognosis%20of%20patients%20with%20hepatic%20epithelioid%20hemangioendothelioma&offset=0&pcAvailability=true
Publisher
ANNALS OF SURGICAL TREATMENT AND RESEARCH
Location
대한민국
Language
영어
ISSN
2288-6575
Citation Volume
100
Citation Number
3
Citation Start Page
137
Citation End Page
143
Appears in Collections:
Medicine > Medicine
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