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Postresection prognosis of combined hepatocellular carcinoma-cholangiocarcinoma according to the 2010 World Health Organization classification: single-center experience of 168 patients

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Abstract
Purpose: Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) has wide histologic diversity. This study investigated the effects of cHCC-CC histology, according to the 2010 World Health Organization (WHO) classification, on patient prognosis.

Methods: The medical records of patients who underwent surgical resection for cHCC-CC at our institution between July 2012 and June 2019 were retrospectively evaluated.

Results: During the study period, 168 patients, 122 males (72.6%) and 46 females (27.4%), underwent surgical resection for cHCC-CC, including 159 patients (94.6%) who underwent R0 resection. Mean tumor diameter was 4.4 +/- 2.8 cm, and 161 patients (95.8%) had solitary tumors. Histologically, 86 patients (51.2%) had classical type, and 82 (48.8%) had tumors with stem cell (SC) features, including 33 (19.6%) with intermediate-cell and 23 (13.7%) each with typical SC and cholangiolocellular features; 3 tumors (1.8%) were unclassifiable. At 1, 3, and 5 years, tumor recurrence rates were 31.9%, 49.6%, and 58.1%, respectively, and patient survival rates were 91.0%, 70.2%, and 60.3%, respectively. Univariate analysis showed that tumor size of >5 cm, microscopic and macroscopic vascular invasion, lymph node metastasis, 8th edition of the American Joint Committee on Cancer (AJCC) tumor stage, and 2010 WHO classification were significantly prognostic. Multivariate analysis showed that the 8th AJCC tumor stage and 2010 WHO histologic classification were independently prognostic for tumor recurrence and patient survival. There were no significant prognostic differences among the 3 SC subtypes.

Conclusion: Postresection outcomes are better in patients with SC-type than with classical-type cHCC-CC.
Author(s)
김기훈김민재문덕복박길춘송기원안철수정동환하태용홍승모황신
Issued Date
2021
Type
Article
Keyword
Combined tumorHepaticHepatocellular carcinomaOriginalProgenitor cellsStem cells일반외과학
DOI
10.4174/astr.2021.100.5.260
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8534
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9778368&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Postresection%20prognosis%20of%20combined%20hepatocellular%20carcinoma-cholangiocarcinoma%20according%20to%20the%202010%20World%20Health%20Organization%20classification:%20single-center%20experience%20of%20168%20pat&offset=0&pcAvailability=true
Publisher
ANNALS OF SURGICAL TREATMENT AND RESEARCH
Location
대한민국
Language
영어
ISSN
2288-6575
Citation Volume
100
Citation Number
5
Citation Start Page
260
Citation End Page
269
Appears in Collections:
Medicine > Medicine
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