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Absence of association between pretransplant serum soluble programmed death protein-1 level and prognosis following living donor liver transplantation in patients with hepatocellular carcinoma

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Abstract
Programmed death protein 1 (PD-1) pathway is one of the most critical mechanisms in tumor biology of hepatocellular carcinoma (HCC). The study aimed to assess the prognostic influence of pretransplant serum soluble PD-1 (sPD-1) in patients undergoing liver transplantation for treatment of HCC. Data from 229 patients with HCC who underwent living donor liver transplantation between January 2010 and December 2015 were retrospectively evaluated. Stored serum samples were used to measure sPD-1 concentrations. Overall survival (OS) and disease-free survival (DFS) rates were 94.3% and 74.5% at 1 year; 78.2% and 59.2% at 3 years; and 75.4% and 55.5% at 5 years, respectively. Prognostic analysis using pretransplant serum sPD-1 with a cut-off of 93.6 mu g/mL (median value of the study cohort) did not have significant prognostic influence on OS (P = .69) and DFS (P = .26). Prognostic analysis using sPD-1 with a cut-off of 300 mu g/mL showed similar OS (P = .46) and marginally lower DFS (P = .070). Combination of Milan criteria and sPD-1 with a cutoff of 300 mu g/mL showed similar outcomes of OS and DFS in patients within and beyond Milan criteria. Multivariate analysis revealed that only Milan criteria was an independent prognostic for OS and DFS, but pretransplant sPD1 with a cut-off of 300 mu g/mL did not become a prognostic factor. The results of this study demonstrate that pretransplant serum sPD-1 did not show significant influences on post-transplant outcomes in patients with HCC. Further large-scale, multicenter studies are necessary to clarify the role of serum sPD-1 in liver transplantation recipients.
Author(s)
김기훈문덕복박길춘송기원안철수윤영인이승규정동환하태용황신Byeong-Gon NaEunyoung TakHunji YangKyung Jin LeeYo-Han ParkYun Kyu Kim
Issued Date
2021
Type
Article
Keyword
7100Abridged Index MedicusAdultCarcinomaHepatocellular - bloodCarcinomaHepatocellular - mortalityCarcinomaHepatocellular - surgeryDisease-Free SurvivalFemalehepatocellular carcinomaHumansimmune checkpointLiver Neoplasms - bloodLiver Neoplasms - mortalityLiver Neoplasms - surgeryLiver Transplantation - methodsLiver Transplantation - mortalityLiving DonorsMaleMiddle AgedMultivariate AnalysisObservational StudyPredictive Value of TestsPreoperative PeriodPrognosisProgrammed Cell Death 1 Receptor - bloodrecurrenceReference ValuesRetrospective StudiesTreatment Outcometumor biology
DOI
10.1097/MD.0000000000025640
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8536
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8084037&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Absence%20of%20association%20between%20pretransplant%20serum%20soluble%20programmed%20death%20protein-1%20level%20and%20prognosis%20following%20living%20donor%20liver%20transplantation%20in%20patients%20with%20hepatocellular%20carci&offset=0&pcAvailability=true
Publisher
MEDICINE
Location
미국
Language
영어
ISSN
0025-7974
Citation Volume
100
Citation Number
17
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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