KLI

Prognostic Accuracy of the ADV Score Following Resection of Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis

Metadata Downloads
Abstract
Background WeassessedtheprognosticaccuracyofADVscore(α-fetoprotein[AFP]-des-γ-carboxyprothrombin[DCP]-tumor volume [TV] score) following resection of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). Methods This was a retrospective observational study. This study included 147 patients who underwent hepatic resection for HCC with PVTT. They were followed up for ≥ 66 months or until patient death. Results The grades of PVTT were Vp1 in 121 (14.3%), Vp2 in 41 (27.9%), Vp3 in 71 (48.3%), and Vp4 in14 (9.5%) cases. PreoperativeHCCtreatmentwasperformedin48(32.7%)patients.R0andR1resectionswereperformedin119(81.0%)and28 (19.0%)cases,respectively.The5-yeartumorrecurrence,HCC-specificsurvival,andpost-recurrencesurvivalrateswere79.2%, 43.5%, and 25.4%, respectively. Neither PVTT grade nor history of preoperative HCC treatment was a significant prognostic indicator. Stratification in accordance with ADV scores of 1log- and 3log-intervals resulted in high prognostic accuracy in predicting tumor recurrence and patient survival. Following cluster analysis, the cutoff for ADV score was determined at 9log and was more prognostically significant in terms of tumor recurrence and patient survival than surgical curability or microvascularinvasion.FurthercomparisonsrevealedthatprognosticpredictionwithanADVscorecutoffat9logwasmoreaccuratethan that using the Eastern Hepatobiliary Surgery Hospital-PVTT score. Conclusions ADV score is an integrated surrogate biomarker for post-resection prognosis in HCC with PVTT. Our prognostic prediction model using ADV scores provides reliable post-resection prognosis for patients with various grades of these tumors.
Author(s)
김기훈문덕복박길춘송기원안철수이승규정동환황신
Issued Date
2021
Type
Article
Keyword
AccuracyAnalysisBlood clotGastroenterologyGlycoproteinsHepatomaLiver cancerMedical collegesMedical prognosisMedical researchMedicineMedicine & Public HealthMedicineExperimentalOriginal ArticlePatientsSurgeryThrombosis
DOI
10.1007/s11605-020-04800-6
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8546
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2444378954&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Prognostic%20Accuracy%20of%20the%20ADV%20Score%20Following%20Resection%20of%20Hepatocellular%20Carcinoma%20with%20Portal%20Vein%20Tumor%20Thrombosis&offset=0&pcAvailability=true
Publisher
JOURNAL OF GASTROINTESTINAL SURGERY
Location
미국
Language
한국어
ISSN
1091-255X
Citation Volume
25
Citation Number
7
Citation Start Page
1745
Citation End Page
1759
Appears in Collections:
Medicine > Medicine
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.