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Clinical Outcomes Between a Minimally Invasive and Open Extended Cholecystectomy for T2 Gallbladder Cancer: A Propensity Score Matching Analysis

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Abstract
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Background: Although a minimally invasive extended cholecystectomy (MIEC) for T2 gallbladder cancer (T2 GBC) has been performed in many experienced centers, no oncologic comparison with open extended cholecystectomy (OEC) has yet been reported. Methods: T2 GBC patients who underwent MIEC (n = 60) or OEC (n = 135) were enrolled. We used propensity score matching (PSM) using pre- and intraoperative variables. Short- and long-term outcomes were then compared before and after PSM. Results: Before PSM, OEC patients more frequently showed completion of surgery after a simple cholecystectomy (standardized mean difference [SMD] = -0.551), and lymph node enlargement on preoperative computed tomography (SMD = -0.471). PSM was used to select 56 patients from each of the 2 patient groups. MIEC patients showed comparable complication rate (7.1% versus 12.5%, P = .365) and shorter hospital stay (5.7 days versus 9.8 days, P < .001). The median follow-up period was 26.2 months, and 5-year overall survival (OS) rate (96.8% versus 91.1%, P = .464) and 5-year recurrence free survival (RFS) (54.7% versus 44.4%, P = .580) outcomes were still comparable between MIEC and OEC groups. Conclusion: MIEC have advantages such as early recovery and comparable short-term outcomes compared with OEC. MIEC showed comparable OS and RFS outcomes compared with OEC. MIEC is a safe option without oncological compromise for T2 GBC.
Author(s)
곽봉준김규민김송철박예종송기병이우형이재훈황대욱
Issued Date
2021
Type
Article
Keyword
gallbladder cancerlaparoscopyprognosisrecurrencesurvival
DOI
10.1089/lap.2021.0417
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8556
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2560833517&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Clinical%20Outcomes%20Between%20a%20Minimally%20Invasive%20and%20Open%20Extended%20Cholecystectomy%20for%20T2%20Gallbladder%20Cancer:%20A%20Propensity%20Score%20Matching%20Analysis&amp;pcAvailability=true
Publisher
Journal of Laparoendoscopic & Advanced Surgical Techniques
Location
미국
Language
영어
ISSN
1092-6429
Citation Volume
online
Citation Number
online
Citation Start Page
online
Citation End Page
online
Appears in Collections:
Medicine > Medicine
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