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Establishment of Pediatric Reference Intervals for Routine Laboratory Tests in Korean Population: A Retrospective Multicenter Analysis

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Abstract
Background: Reference intervals defined for adults or children of other ethnicities cannot be applied in the evaluation of Korean pediatric patients. Pediatric reference intervals are difficult to establish because children are in their growing stage and their physiology changes continuously. We aimed to establish reference intervals for routine laboratory tests for Korean pediatric patients through retrospective multicenter data analysis.

Methods: Preoperative laboratory test results from 1,031 pediatric patients aged 0 month-18 years who underwent minor surgeries in four university hospitals were collected. Age- and sex-specific reference intervals for routine laboratory tests were defined based on the Clinical and Laboratory Standards Institute (CLSI) EP28-A3c guidelines.

Results: The pediatric reference intervals determined in this study were different from existing adult reference intervals and pediatric reference intervals for other ethnicities. Most tests required age-specific partitioning, and some of those required sex-specific partitioning for at least one age-partitioned subgroup. Erythrocyte sedimentation rate, monocyte percentage, basophil percentage, activated partial thromboplastin time, glucose, cholesterol, albumin, bilirubin, chloride, and C-reactive protein did not show any difference between age- or sex-partitioned subgroups.

Conclusions: We determined Korean pediatric reference intervals for hematology, coagulation, and chemistry tests by indirect sampling based on medical record data from multiple institutions. These reference intervals would be valuable for clinical evaluations in the Korean pediatric population.
Author(s)
성지연서종도고대현박민정황상미오소희전사일성문우송정한송상훈박성섭
Issued Date
2021
Type
Article
Keyword
Reference intervalsIndirect samplingKorean pediatricsAge-partitioned groupsSex-partitioned groupsMulticenter
DOI
10.3343/alm.2021.41.2.155
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8582
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9748990&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Establishment%20of%20Pediatric%20Reference%20Intervals%20for%20Routine%20Laboratory%20Tests%20in%20Korean%20Population:%20A%20Retrospective%20Multicenter%20Analysis&offset=0&pcAvailability=true
Publisher
ANNALS OF LABORATORY MEDICINE
Location
대한민국
Language
영어
ISSN
2234-3806
Citation Volume
41
Citation Number
2
Citation Start Page
155
Citation End Page
155
Appears in Collections:
Medicine > Medicine
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