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Evaluation of safety of using incompatible plasma for therapeutic plasma exchange during shortage of AB plasma

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Abstract
Background Criteria for selection of FFP blood type has not been clearly established and use of group AB plasma is preferred by numerous transplantation protocols.

Aims This study assesses the safety and efficacy of alternative group A or B plasma in ABO incompatible solid organ transplantation.

Materials Methods Alternative use of group A or B plasma (incompatible plasma) was inevitable during the shortage of group AB plasma. Experience from select number of patients during the period of extreme group AB plasma shortage is described.

Results The result of alternative use of group A or B plasma was within expectation, showing effective reduction of isoagglutinin titers for pre-operative desensitization and efficacy for treatment of post-operative patients. No immediate hemolytic transfusion reaction was reported.

Discussion While validation in a larger cohort of patients is necessary, our limited experience have shown satisfactory clinical outcomes without adverse events.

Conclusions Use of incompatible group A or B plasma is a viable option when group AB plasma is limited.
Author(s)
고대현김진석김형석류경숙양정석오흥범정유선황상현
Issued Date
2021
Type
Article
Keyword
desensitizationhemolysisincompatibleplasmasafetytherapeutic plasma exchange
DOI
10.1002/jca.21904
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8590
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2522400275&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Evaluation%20of%20safety%20of%20using%20incompatible%20plasma%20for%20therapeutic%20plasma%20exchange%20during%20shortage%20of%20AB%20plasma&offset=0&pcAvailability=true
Publisher
JOURNAL OF CLINICAL APHERESIS
Location
미국
Language
영어
ISSN
0733-2459
Citation Volume
36
Citation Number
4
Citation Start Page
628
Citation End Page
633
Appears in Collections:
Medicine > Medicine
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