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Reduced Brainstem Volume After Mild Traumatic Brain Injury

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Abstract
Objective

The aims of this study were to investigate changes in regional brain volume after concussion (mild traumatic brain injury) and to examine the relationship between change in brain volume and cognitive deficits. Design

Twenty-eight patients with mild traumatic brain injury and 27 age-matched controls were included in this study. Magnetic resonance imaging (3 T) data were obtained from the participants. Structural brain volume changes were examined using tensor-based morphometry, which identifies regional structural differences in the whole brain, including cerebrospinal fluid, gray matter, and white matter. Volume contraction and expansion were compared between groups using a two-sample t test. The association between time post-injury or neurocognitive function and volumetric changes was examined using regression analysis. Results

Individuals with mild traumatic brain injury exhibited volume reduction in the brainstem, including the pontine reticular formation. Regional cerebral volume changes were not associated with time post-injury but were significantly associated with neurocognitive function, especially with executive card sorting test, forward digit span test, and performance on verbal learning test. The greater regional cerebral volume was associated with better cognitive performance after mild traumatic brain injury. Conclusion

Decreased brainstem volume may indicate its vulnerability to traumatic injury, and cerebral volume in specific regions was positively associated with patients' cognitive function after injury.
Author(s)
김은형서한길이현행이승학최승홍유노을조원상윤서정강민구오병모
Issued Date
2021
Type
Article
Keyword
ConcussionTraumatic Brain InjuryMagnetic Resonance ImagingNeuroimaging
DOI
10.1097/PHM.0000000000001580
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8611
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2440468960&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Reduced%20Brainstem%20Volume%20After%20Mild%20Traumatic%20Brain%20Injury&offset=0&pcAvailability=true
Publisher
AMERICAN JOURNAL OF PHYSICAL MEDICINE REHABILITATION
Location
미국
Language
영어
ISSN
0894-9115
Citation Volume
100
Citation Number
5
Citation Start Page
473
Citation End Page
482
Appears in Collections:
Medicine > Medicine
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