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Association of the First Antipsychotic Treatment Duration With the Re-Initiation of Treatment in Schizophrenia: A National Health Insurance Data-Based Study

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Abstract
Objectives
The optimal duration of maintenance treatment for patients with first-episode schizophrenia (FES) remains unclear. We examined the first antipsychotic treatment duration and its association with re-initiation of treatment using a nationwide claim database.
Methods
Data from the Health Insurance Review and Assessment Service database in South Korea for 2007-2016 were used. Linear regression analysis and Cox proportional hazard models were used to evaluate the associations between the duration of the first antipsychotic treatment, time to re-initiation of treatment, and occurrence of treatment re-initiation.
Results
Of 30,143 patients with FES, 80.4% (n=24,231) received <2 years of the first antipsychotic treatment. In patients who discontinued treatment (n=23,030), the rate of treatment re-initiation was 74.2% (n=17,086). As the duration of the first antipsychotic treatment increased, the time to re-initiation of treatment decreased (β=-0.146, p<0.001); however, the rate of treatment re-initiation was relatively constant (hazard ratio=1.001, p<0.001).
Conclusion
Long-term antipsychotic treatment was not significantly associated with the rate of treatment re-initiation but showed a negative association with the time to re-initiation of treatment. Further research is needed to better understand the optimal treatment duration for FES.
Author(s)
김하린송민호안수진이중선조영탁주성우최영재
Issued Date
2021
Type
Article
Keyword
Antipsychotic treatment&nbsp;Re-initiation of treatment&nbsp;Schizophrenia
DOI
10.16946/kjsr.2021.24.2.60
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8641
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9873159&amp;context=PC&amp;vid=ULSAN&amp;lang=ko_KR&amp;search_scope=default_scope&amp;adaptor=primo_central_multiple_fe&amp;tab=default_tab&amp;query=any,contains,Association%20of%20the%20First%20Antipsychotic%20Treatment%20Duration%20With%20the%20Re-Initiation%20of%20Treatment%20in%20Schizophrenia:%20A%20National%20Health%20Insurance%20Data-Based%20Study&amp;offset=0&amp;pcAvailability=true
Publisher
Korean Journal of Schizophrenia Research
Location
대한민국
Language
영어
ISSN
2287-6995
Citation Volume
24
Citation Number
2
Citation Start Page
60
Citation End Page
67
Appears in Collections:
Medicine > Medicine
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