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Investigating Sexual Dimorphism of Human White Matter in a Harmonized, Multisite Diffusion Magnetic Resonance Imaging Study

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Abstract
Axonal myelination and repair, critical processes for brain development, maturation, and aging, remain controlled by sexual hormones. Whether this influence is reflected in structural brain differences between sexes, and whether it can be quantified by neuroimaging, remains controversial. Diffusion-weighted magnetic resonance imaging (dMRI) is an in vivo method that can track myelination changes throughout the lifespan. We utilize a large, multisite sample of harmonized dMRI data (n?=?551, age?=?9?65 years, 46% females/54% males) to investigate the influence of sex on white matter (WM) structure. We model lifespan trajectories of WM using the most common dMRI measure fractional anisotropy (FA). Next, we examine the influence of both age and sex on FA variability. We estimate the overlap between male and female FA and test whether it is possible to label individual brains as male or female. Our results demonstrate regionally and spatially specific effects of sex. Sex differences are limited to limbic structures and young ages. Additionally, not only do sex differences diminish with age, but tracts within each subject become more similar to one another. Last, we show the high overlap in FA between sexes, which implies that determining sex based on WM remains open.
Author(s)
이중선Anil MalhotraBrett ClementzCarol TammingaDavid SchretlenGodfrey PearlsonInga K KoerteJohanna SeitzJohn SweeneyKatharina StegmayerKatharina StegmayerMadhura BaxiMarek KubickiMark VangelMartha E ShentonMatcheri KeshavanOfer PasternakPetra Verena ViherPhilip R SzeszkoPhilip R Sz
Issued Date
2021
Type
Article
Keyword
AdolescentAdultAgedAnisotropyAxons - physiologyChildDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleHumansLimbic System - diagnostic imagingLimbic System - physiologyMaleMiddle AgedMyelin Sheth - physiologyNeural Pathways - diagnostic imagingNeural pathways - physiologySex CharacteristicsWhite Matter - anatomy & histologyWhite Maatter - diagnostic imagingYoung Adult
DOI
10.1093/cercor/bhaa220
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8642
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2437848706&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Investigating%20Sexual%20Dimorphism%20of%20Human%20White%20Matter%20in%20a%20Harmonized,%20Multisite%20Diffusion%20Magnetic%20Resonance%20Imaging%20Study&offset=0&pcAvailability=true
Publisher
CEREBRAL CORTEX
Location
영국
Language
한국어
ISSN
1047-3211
Citation Volume
31
Citation Number
1
Citation Start Page
201
Citation End Page
212
Appears in Collections:
Medicine > Medicine
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