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Effects of comorbid alcohol use disorder on the clinical outcomes of first-episode schizophrenia: a nationwide population-based study

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Abstract
Background: Alcohol use disorder (AUD) is a common psychiatric comorbidity in schizophrenia, associated with poor clinical outcomes and medication noncompliance. Most previous studies on the effect of alcohol use in patients with schizophrenia had limitations of small sample size or a cross-sectional design. Therefore, we used a nationwide population database to investigate the impact of AUD on clinical outcomes of schizophrenia.

Methods: Data from the Health Insurance Review Agency database in South Korea from January 1, 2007 to December 31, 2016 were used. Among 64,442 patients with first-episode schizophrenia, 1598 patients with comorbid AUD were selected based on the diagnostic code F10. We performed between- and within-group analyses to compare the rates of psychiatric admissions and emergency room (ER) visits, and medication possession ratio (MPR) between the patients with comorbid AUD and control patients matched for the onset age, sex, and observation period.

Results: The rates of psychiatric admissions and ER visits in both groups decreased after the time point of diagnosis of AUD; however, the decrease was significantly greater in the patients with comorbid AUD compared to the control patients. While the comorbid AUD group showed an increase in MPR after the diagnosis of AUD, MPR decreased in the control group. The rates of psychiatric admissions, ER visits, and MPR were worse in the comorbid AUD group both before and after the diagnosis of AUD.

Conclusions: The results emphasize an importance of psychiatric comorbidities, especially AUD, in first-episode schizophrenia and the necessity of further research for confirmative findings of the association of AUD with clinical outcomes of schizophrenia.
Author(s)
김하린안수진이중선조영탁주성우최영재최우혁
Issued Date
2021
Type
Article
Keyword
Alcohol use disorderAlcoholismComorbidityDrug ComplianceHospitalizationpatient outcomesPrimary ResearchPsychological aspectsSchizophrenia
DOI
10.1186/s12991-021-00353-3
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8645
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_fc008c766c8e465583151a491456258f&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Effects%20of%20comorbid%20alcohol%20use%20disorder%20on%20the%20clinical%20outcomes%20of%20first-episode%20schizophrenia:%20a%20nationwide%20population-based%20study&offset=0&pcAvailability=true
Publisher
Annals of General Psychiatry
Location
대한민국
Language
영어
ISSN
1744-859X
Citation Volume
20
Citation Number
1
Citation Start Page
32
Citation End Page
32
Appears in Collections:
Medicine > Medicine
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