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Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin

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Abstract
Background: Ginsenosides of Panax ginseng are used to enhance skin health and beauty. The present study aimed to investigate the potential use of ginsenoside Rf (Rf) from Panax ginseng as a new anti pigmentation agent. Methods: The anti-melanogenic effects of Rf were explored. The transcriptional activity of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related proteins (Tyrps) were evaluated in melanocytes and UV-irradiated ex vivo human skin. Results: Rf significantly inhibited Forskolin (FSK) or UV-stimulated melanogenesis. Consistently, cellular tyrosinase activity and levels of MITF, tyrosinase, and Tyrps were downregulated. Furthermore, Rf suppressed MITF promoter activity, which was stimulated by FSK or CREB-regulated transcription coactivator 3 (CRTC3) overexpression. Increased CREB phosphorylation and protein kinase A (PKA) activity induced by FSK were also mitigated in the presence of Rf. Conclusion: Rf can be used as a reliable anti-pigmentation agent, which has a scientifically confirmed and reproducible action mechanism, via inhibition of CREB/MITF pathway. (c) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Author(s)
이하리정준민서지연장성은송영섭
Issued Date
2021
Type
Article
Keyword
Panax ginsenganti-pigmentation agentCREB/MITF pathwayginsenoside Rf
DOI
10.1016/j.jgr.2020.11.003
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8741
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9895303&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Anti-melanogenic%20property%20of%20ginsenoside%20Rf%20from%20Panax%20ginseng%20via%20inhibition%20of%20CREB%2FMITF%20pathway%20in%20melanocytes%20and%20ex%20vivo%20human%20skin&offset=0&pcAvailability=true
Publisher
JOURNAL OF GINSENG RESEARCH
Location
대한민국
Language
한국어
ISSN
1226-8453
Citation Volume
45
Citation Number
5
Citation Start Page
555
Citation End Page
564
Appears in Collections:
Medicine > Medicine
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