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Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation

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Abstract
Extrinsic aging of the skin caused by ultraviolet (UV) light or particulate matter is often manifested by hyperpigmentation due to increased melanogenesis in senescent skin. Ursodeoxycholic acid (UDCA), which has been commonly used as a health remedy for liver diseases, is known to possess antioxidant properties. This study was done to investigate whether UDCA inhibits cellular aging processes in the cells constituting human skin and it reduces melanin synthesis. ROS, intracellular signals, IL-1 alpha, IL-8, TNF-alpha, cyclooxygenase (COX)-2, type I collagen, and matrix metalloproteinases (MMPs) levels were measured in human dermal fibroblasts treated with or without UDCA after UV exposure. Melanin levels and mechanistic pathways for melanogenesis were investigated. UDCA decreased ROS, senescence-associated secretory phenotype (SASP), and proinflammatory cytokines induced by UV treatment. UDCA reduced melanogenesis in normal human melanocytes cocultured with skin constituent cells. Our results suggest that UDCA could be a comprehensive agent for the treatment of environmental aging-associated hyperpigmentation disorders.
Author(s)
문익준유한주백승환김학태김수연송영섭장성은
Issued Date
2021
Type
Article
Keyword
ursodeoxycholic acidantioxidantphotoagingenvironmental agingparticulate matterhyperpigmentationfibroblastsultraviolet light
DOI
10.3390/antiox10020267
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8742
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_9e389fd971ee4dfba8c3636cb58b7924&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Ursodeoxycholic%20Acid%20May%20Inhibit%20Environmental%20Aging-Associated%20Hyperpigmentation&offset=0&pcAvailability=true
Publisher
ANTIOXIDANTS
Location
스위스
Language
한국어
ISSN
2076-3921
Citation Volume
10
Citation Number
2
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Medicine > Medicine
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