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Therapeutic New Era for Atopic Dermatitis: Part 1. Biologics

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Abstract
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. We are currently experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. Recently, advances in translational research have challenged the traditional AD pathogenesis paradigm of AD being solely a Th2-dominant disease. Other immune pathways seem to play a role in the complex AD pathophysiology, although the clinical relevance of these additional immune pathway abnormalities is unclear. Type 1, type 22, and type 17 pathway activation (with related cytokines/chemokines) have been demonstrated in the skin and blood of AD patients. Type 2 (interleukin [IL]-4, IL-13), IL-31, and type 22 (IL-22) pathway cytokines are increased in AD acute lesions. IL-22 induces both an epidermal hyperplasia at the onset of acute AD and a marked increase in the terminal differentiation S100 genes. This understanding of pathogenesis corresponds to a historic increase in therapeutic development in AD. The extreme clinical heterogeneity and the chronic progression of AD establish the need for newer, safer, and more effective treatments, control the disease, and improve the quality of life of affected patients.
Author(s)
안지영최유성Eric Lawrence Simpson
Issued Date
2021
Type
Article
Keyword
Atopic dermatitisBiologicsNew eraTherapeutics.
DOI
10.5021/ad.2021.33.1.1
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8751
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_kiss_primary_3846019&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Therapeutic%20New%20Era%20for%20Atopic%20Dermatitis:%20Part%201.%20Biologics&offset=0&pcAvailability=true
Publisher
ANNALS OF DERMATOLOGY
Location
대한민국
Language
영어
ISSN
1013-9087
Citation Volume
33
Citation Number
1
Citation Start Page
1
Citation End Page
10
Appears in Collections:
Medicine > Medicine
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