Primary Graft Dysfunction After Isolated Heart Transplantation - Incidence, Risk Factors, and Clinical Implications Based on a Single-Center Experience -
- Abstract
- Background: Since the international consensus on primary graft dysfunction (PGD) following heart transplantation (HT) was reported in 2014, few clinical studies have been reported. We aimed to analyze the incidence, predictive factors, and clinical implications of PGD following the International Society of Heart and Lung Transplant criteria in a single center.
Methods and Results: This study enrolled 570 consecutive adult patients undergoing isolated HT between November 1992 and December 2017. Under a new set of criteria, PGD-left ventricle (PGD-LV) occurred in 35 patients (6.1%; mild, n=1 [0.2%]; moderate, n=14 [2.5%]; severe, n=20 [3.5%]), whereas PGD-right ventricle (PGD-RV) occurred in 3 (0.5%). Multivariable analysis demonstrated that preoperative admission (odds ratio [OR] 4.20; 95% confidence interval [CI] 1.24-14.26; P=0.021), preoperative extracorporeal membrane oxygenation (OR 4.03; 95% CI 1.75-9.26; P=0.001), and prolonged total ischemic time (OR 1.09; 95% CI 1.02-1.15; P=0.006) were significant predictors of moderate to severe PGD-LV. Moderate to severe PGD-LV was an independent and significant risk factor for early death (OR 55.64; 95% CI 11.65-265.73; P<0.001), with its effects extending up to 3 months after HT.
Conclusions: Moderate to severe PGD-LV, as defined by the new guidelines, is an important predictor of early mortality, with effects extending up to 3 months after HT. Efforts to reduce the occurrence of moderate to severe PGD-LV may lead to better outcomes.
- Author(s)
- 이연주; 김호진; 김재중; 김민석; 이상은; 윤태진; 이재원; 정성호
- Issued Date
- 2021
- Type
- Article
- Keyword
- Heart transplantation; Primary graft dysfunction; Risk factors
- DOI
- 10.1253/circj.CJ-20-0960
- URI
- https://oak.ulsan.ac.kr/handle/2021.oak/8773
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2515070199&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Primary%20Graft%20Dysfunction%20After%20Isolated%20Heart%20Transplantation%20-%20Incidence,%20Risk%20Factors,%20and%20Clinical%20Implications%20Based%20on%20a%20Single-Center%20Experience%20-&offset=0&pcAvailability=true
- Publisher
- CIRCULATION JOURNAL
- Location
- 일본
- Language
- 영어
- ISSN
- 1346-9843
- Citation Volume
- 85
- Citation Number
- 9
- Citation Start Page
- 1451
- Citation End Page
- 1459
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Appears in Collections:
- Medicine > Medicine
- 공개 및 라이선스
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