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The Advantages of Indocyanine Green Fluorescence Imaging in Detecting and Treating Pediatric Hepatoblastoma: A Preliminary Experience

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Abstract
Background: Currently, indocyanine green (ICG) fluorescence imaging enables radical surgical resection in hepatoblastoma (HB) and has beneficial uses; however, its usage in pediatric patients is still limited.

Methods: From 2015 to 2019, 17 hepatoblastoma patients underwent 22 fluorescence-guided surgery using ICG. ICG (0.3 mg/kg) was intravenously injected 24-48 h before the operation. With ICG/NIR camera, intraoperative identification of biological structures and demarcation of mass were conducted.

Results: ICG fluorescence-guided surgery was performed for hepatoblastoma in 22 cases: 16, 1, and 2 cases underwent anatomic resection, partial hepatectomy, and liver transplantation, respectively. Six patients accompanied lung metastasis at the time of surgery, and two patients underwent lung surgery using ICG. The median interval from ICG injection to surgery was 38.3 h (range, 20.5-50.3 h). The median tumor size was 36.5 mm (range, 2-132 mm). According to the pathologic finding, the median safety margin was secured for 6 mm (range, 0-11 mm) and there was no residual finding at the liver at the follow-up computed tomography (CT).

Conclusions: ICG fluorescence imaging in children with HB was feasible and safe for tumor demarcation and enhancing the accuracy of radical tumor resection.
Author(s)
조유정남궁정만권현희권용재김대연김송철
Issued Date
2021
Type
Article
Keyword
indocyanine greenhepatoblastomafluorescencepediatricsR0 resection
DOI
10.3389/fped.2021.635394
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8929
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_434b7f40c85d4e57b72b489353425df5&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,The%20Advantages%20of%20Indocyanine%20Green%20Fluorescence%20Imaging%20in%20Detecting%20and%20Treating%20Pediatric%20Hepatoblastoma:%20A%20Preliminary%20Experience&offset=0&pcAvailability=true
Publisher
FRONTIERS IN PEDIATRICS
Location
스위스
Language
한국어
ISSN
2296-2360
Citation Volume
9
Citation Number
0
Citation Start Page
0
Citation End Page
0
Appears in Collections:
Engineering > Medical Engineering
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