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Folic Acid Functionalized Carbon Dot/Polypyrrole Nanoparticles for Specific Bioimaging and Photothermal Therapy

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Abstract
Polypyrrole nanoparticles (PPy-NPs) with excellent near-infrared absorption are commonly used as photothermal therapy (PTT) agents; however, PTT using PPy-NPs has a limitation in that it is difficult to maximize their therapeutic effect because of the lack of specific targeting. In this study, to overcome the difficulty of targeting, folic acid functionalized carbon dots (FA-CDs) with bright green fluorescence properties were combined with carboxylated PPy-NPs via the EDC/NHS coupling reaction to yield a PTT imaging agent. The synthesized FA-CD/PPy-NPs with excellent photostability performed folate receptor (FR) positive HeLa cancer cell imaging by green fluorescence signals of FA-CDs and exhibited high cell viability (above 90%) even at 500 μg/mL. The viability of HeLa cells incubated with 200 μg/mL FA-CD/PPy-NPs was dramatically decreased to 25.02 ± 1.85% by NIR laser irradiation, through photothermal therapeutic effects of FA-CD/PPy-NPs with high photothermal conversion efficiency (η = 40.80 ± 1.54%). The cancer cell death by FA-CD/PPy-NPs was confirmed by fluorescence imaging of FA-CDs as well as live/dead cell staining assay (calcein-AM/PI). These results demonstrate that the FA-CD/PPy-NPs can be utilized as multifunctional theranostic agents for specific bioimaging and treatment of FR-positive cancer cells.
Author(s)
Tae Eun KimHyeon Jeong JangSeok Won ParkJie Wei조신욱Woon Ik ParkBo Ram LeeChang Duk YangYun Kyung Jung
Issued Date
2021
Type
Article
Keyword
Carbon DotNanoparticlesBioimagingPhotothermal Therapy
DOI
10.1021/acsabm.1c00018
URI
https://oak.ulsan.ac.kr/handle/2021.oak/8978
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_crossref_primary_10_1021_acsabm_1c00018&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Folic%20Acid%20Functionalized%20Carbon%20Dot%2FPolypyrrole%20Nanoparticles%20for%20Specific%20Bioimaging%20and%20Photothermal%20Therapy&offset=0&pcAvailability=true
Publisher
ACS Applied Bio Materials
Location
미국
Language
영어
ISSN
2576-6422
Citation Volume
4
Citation Number
4
Citation Start Page
3453
Citation End Page
3461
Appears in Collections:
Engineering > Material Engineering
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