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Enhancement of sophorolipids production in Candida batistae, an unexplored sophorolipids producer, by fed-batch fermentation

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Abstract
Sophorolipids (SLs) from Candida batistae has a unique structure that contains ω?hydroxy fatty acids, which can be used
as a building block in the polymer and fragrance industries. To improve the production of this industrially important SLs,
we optimized the culture medium of C. batistae for the frst time. Using an optimized culture medium composed of 50 g/L
glucose, 50 g/L rapeseed oil, 5 g/L ammonium nitrate and 5 g/L yeast extract, SLs were produced at a concentration of
24.1 g/L in a fask culture. Sophorolipids production increased by about 19% (28.6 g/L) in a fed-batch fermentation using
a 5 L fermentor. Sophorolipids production more increased by about 121% (53.2 g/L), compared with that in a fask culture,
in a fed-batch fermentation using a 50 L fermentor, which was about 787% higher than that of the previously reported SLs
production (6 g/L). These results indicate that a signifcant increase in C. batistae-derived SLs production can be achieved
by optimization of the culture medium composition and fed-batch fermentation. Finally, we successfully separated and purifed the SLs from the culture medium. The improved production of SLs from C. batistae in this study will help facilitate the
successful development of applications for the SLs.
Author(s)
김중헌안정훈엄경태오유리장영아한상우홍순호
Issued Date
2021
Type
Article
Keyword
Ammonium compoundsAmmonium paratungstateBioreactorsBiotechnologyBiotechnology - methodsCandidaCarbon - chemistryChemistryChemistry and Materials ScienceCulture Media - chemistryEnvironmental Engineering/BiotechnologyFatty AcidsFermentationFood ScienceGlucose - chemistryGlycolipids - biosynthesisIndustrial and Production EngineeringIndustrial Chemistry/Chemical EngineeringIndustrial Microbiology - methodsNitrates - chemistryOleic Acids - chemistryPlant Oils - chemistryRapeseed Oil - chemistryResearch institutesResearch PaperSaccharomycetales - metabolismSurface-Active Agents - chemistry
DOI
10.1007/s00449-020-02493-4
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9235
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2499006737&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Enhancement%20of%20sophorolipids%20production%20in%20Candida%20batistae,%20an%20unexplored%20sophorolipids%20producer,%20by%20fed-batch%20fermentation&offset=0&pcAvailability=true
Publisher
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Location
미국
Language
영어
ISSN
1615-7591
Citation Volume
44
Citation Number
4
Citation Start Page
831
Citation End Page
839
Appears in Collections:
Engineering > Chemical Engineering
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