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Transient receptor potential channel-dependent myogenic responsiveness in small-sized resistance arteries

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Abstract
It is well documented that the inherent ability of small arteries and arterioles to regulate intraluminal diameter in response to alterations in intravascular pressure determines peripheral vascular resistance and blood flow (termed myogenic response or pressure-induced vasoconstriction/dilation). This autoregulatory property of resistance arteries is primarily originated from mechanosensitive vascular smooth muscle cells (VSMCs). There are diverse biological apparatuses in the plasma membrane of VSMCs that sense mechanical stimuli and generate intracellular signals for the contractility of VSMCs. Although the roles of transient receptor potential (TRP) channels in pressure-induced vasoconstriction are not fully understood to date, TRP channels that are directly activated by mechanical stimuli (e.g., stretch of VSMCs) or indirectly evoked by intracellular molecules (e.g., inositol trisphosphate) provide the major sources of Ca2+ (e.g., Ca2+ influx or release from the sarcoplasmic reticulum) and in turn, evoke vascular reactivity. This review sought to summarize mounting evidence over several decades that the activation of TRP canonical, TRP melastatin, TRP vanilloid, and TRP polycystin channels contributes to myogenic vasoconstriction.
Author(s)
김기정홍광석
Issued Date
2021
Type
Article
Keyword
Ion channelMechanotransductionMicrocirculationPressure-induced vasoconstrictionReviewVascular smooth muscle cells심리과학
DOI
10.12965/jer.2040836.418
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9410
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9755881&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Transient%20receptor%20potential%20channel-dependent%20myogenic%20responsiveness%20in%20small-sized%20resistance%20arteries&offset=0&pcAvailability=true
Publisher
Journal of exercise rehabilitation (J. Exerc. Rehabil.)
Location
대한민국
Language
영어
ISSN
2288-176X
Citation Volume
17
Citation Number
1
Citation Start Page
4
Citation End Page
10
Appears in Collections:
Natural Science > Sport Science
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