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Establishment and Long-Term Expansion of Small Cell Lung Cancer Patient-Derived Tumor Organoids

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Abstract
Differential chemo-sensitivity of cancer cells, which is attributed to the cellular heterogeneity and phenotypic variation of cancer cells, is considered to be the main reason for tumor recurrence after chemotherapy. Here, we generated small cell lung cancer patient-derived tumor organoids and subjected them to long-term expansion with the addition of WNT3A or R-spondin1. We confirmed that the organoids have similar genetic profiles, molecular characteristics, and morphological architectures to the corresponding patient tumor tissue during and after long-term expansion. Interestingly, the cellular heterogeneity of organoids is reflected in their differential response to cisplatin or etoposide. We propose to utilize the organoids as small cell lung cancer patient avatar models that would be ideal for investigating the mechanisms underlying tumor recurrence after chemotherapy, and would ultimately help to develop personalized medicine.
Author(s)
최선영조용희김다솜지원준최창민이재철노진경정기석
Issued Date
2021
Type
Article
Keyword
small cell lung cancerpatient-derived tumor organoidspatient avatar model systems
DOI
10.3390/ijms22031349
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9562
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_59218e3c8f8548f19503185460c56d96&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Establishment%20and%20Long-Term%20Expansion%20of%20Small%20Cell%20Lung%20Cancer%20Patient-Derived%20Tumor%20Organoids&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Location
스위스
Language
영어
ISSN
1422-0067
Citation Volume
22
Citation Number
3
Citation Start Page
1349
Citation End Page
1349
Appears in Collections:
Natural Science > Biological Sciences
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