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Enhanced lipid utilization is coupled to the sickness responses triggered by lipopolysaccharide

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Abstract
Sickness symptoms exerted via inflammatory responses occur in several infectious and chronic diseases.
A growing body of evidence suggests that altered nutrient availability and metabolism are tightly
coupled to inflammatory processes. However, the relationship between metabolic shifts and the
development of the sickness response has not been explored fully. Therefore, we aimed to evaluate
metabolic phenotypes with a mouse model showing sickness symptoms via systemic administration of
lipopolysaccharide (LPS) in the present study. LPS injection elevated the lipid utilization and circulating
levels of fatty acids. It also increased the levels of b-hydroxybutyric acid, a ketone body produced from
fatty acids. We confirmed the functional connectivity between nutrient utilization and inflammatory
responses and demonstrated enhanced lipid utilization in the hypothalamus providing insights into
hypothalamic control of sickness responses. Collectively, these findings could help develop new therapeutic strategies to treat patients with severe sickness symptoms associated with infectious and chronic
human diseases.
Author(s)
김양태김예진김재광김재근박병서이병주정다연
Issued Date
2021
Type
Article
Keyword
AnalysisChronic diseasesEnergy metabolismFatty acidsHypothalamusInflammationInnovationsLipopolysaccharideMitogensNutrient utilizationSickness response
DOI
10.1016/j.bbrc.2021.04.043
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9567
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2518740975&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Enhanced%20lipid%20utilization%20is%20coupled%20to%20the%20sickness%20responses%20triggered%20by%20lipopolysaccharide&offset=0&pcAvailability=true
Publisher
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Location
미국
Language
영어
ISSN
0006-291X
Citation Volume
558
Citation Number
1
Citation Start Page
44
Citation End Page
50
Appears in Collections:
Natural Science > Biological Sciences
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