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7-ketocholesterol enhances autophagy via the ROS-TFEB signaling pathway in osteoclasts

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Abstract
Oxysterols play a critical role in human health and diseases associated with high cholesterol and oxidative stress. Given that a positive correlation was observed between cholesterol and collagen type 1 fragment (CTX-1) or serum reactive oxygen species (ROS) in humans, we hypothesized that oxidized cholesterol metabolites may participate in cholesterol-induced bone loss. Therefore, this study aimed to identify the metabolite responsible for cholesterol-associated bone loss and evaluate its effect on osteoclasts (OCs) leading to bone loss. An atherogenic diet in mice increased the levels of the oxysterol, 7-ketocholesterol (7-KC) in bone, as well as serum ROS. 7-KC increased the number and activity of OCs by enhancing autophagy via the ROS-transcription factor EB signaling pathway. These findings suggest that 7-KC acts as a cholesterol metabolite and is at least partially responsible for cholesterol-induced bone loss by inducing autophagy in OCs. (c) 2021 Elsevier Inc. All rights reserved.
Author(s)
설옥주이국은김지은김은숙최혜선
Issued Date
2021
Type
Article
Keyword
7-ketocholesterolosteoclastautophagyreactive oxygen speciestranscription factor EB
DOI
10.1016/j.jnutbio.2021.108783
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9574
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_proquest_miscellaneous_2531543023&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,7-ketocholesterol%20enhances%20autophagy%20via%20the%20ROS-TFEB%20signaling%20pathway%20in%20osteoclasts&offset=0&pcAvailability=true
Publisher
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
Location
미국
Language
영어
ISSN
0955-2863
Citation Volume
96
Citation Number
1
Citation Start Page
108783
Citation End Page
108783
Appears in Collections:
Natural Science > Biological Sciences
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