KLI

Filbertone Protects Obesity-induced Hypothalamic Inflammation by Reduction of Microglia-mediated Inflammatory Responses

Metadata Downloads
Abstract
Abstract Microglial activation is critical for obesityinduced
hypothalamic inflammation and is closely associated
with pathologies of metabolic complications. In this study,
we investigated the effect of filbertone, a main aroma
compound of hazelnuts, on microglia-mediated inflammatory
responses in vitro and obesity-induced hypothalamic
inflammation in vivo. BV2 microglial cells were stimulated
with lipopolysaccharide (LPS) in the presence or absence
of filbertone. Meanwhile, C57BL/6 mice were fed for 10-
weeks on a high-fat diet (HFD) supplemented with 0.2%
filbertone. Levels of inflammatory mediators in microglia
or hypothalamus were measured using enzyme-linked
immunosorbent assays or quantitative real-time PCR.
Filbertone significantly inhibited nitrite oxide production,
inducible nitric oxide synthase expression, and inflammatory
cytokine production in LPS-stimulated microglia. Filbertone
also inhibited LPS-stimulated activation of inflammatory
signaling molecules, mitogen-activated protein kinases
(MAPK) such as extracellular signal-regulated kinases and
p38, and the degradation of inhibitory nuclear factor
kappa-light-chain-enhancer of activated B cells (NF-κB) in
microglia. Moreover, filbertone supplementation markedly
suppressed the expression of inflammatory cytokines and
microglia activation marker in the hypothalamus of obese
mice fed a HFD. These results suggest that filbertone reduces
HFD-induced microglial activation through inhibition of
the MAPK and NF-κB pathways, and thus protects obesityinduced
hypothalamic inflammation. Filbertone may be
useful for protection of microglia-mediated hypothalamic
inflammation in obese condition and related metabolic
complications.
Author(s)
김민선김지예김추숙무스나이니 루피야박태선양지현유리나이찬희T Goto
Issued Date
2021
Type
Article
Keyword
B cellsBiotechnologyBrainChemistryEnzymesIndustrial and Production EngineeringInflammationMedical collegesMiceMitogensNitric oxidePhysiological aspectsProtein kinasesResearch Paper생물공학
DOI
10.1007/s12257-020-0220-5
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9588
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_nrf_kci_oai_kci_go_kr_ARTI_9763254&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Filbertone%20Protects%20Obesity-induced%20Hypothalamic%20Inflammation%20by%20Reduction%20of%20Microglia-mediated%20Inflammatory%20Responses&offset=0
Publisher
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
Location
대한민국
Language
영어
ISSN
1226-8372
Citation Volume
26
Citation Number
1
Citation Start Page
86
Citation End Page
92
Appears in Collections:
Human Ecology > Child and Family Welfare
Authorize & License
  • Authorize공개
Files in This Item:
  • There are no files associated with this item.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.