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Smart Vitamin Micelles as Cancer Nanomedicines for Enhanced Intracellular Delivery of Doxorubicin

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Abstract
Chemotherapy is one of the most effective treatments for cancer. However, intracellular delivery of many anticancer drugs is hindered by their hydrophobicity and low molecular weight. Here,
we describe highly biocompatible and biodegradable amphiphilic vitamin conjugates comprising
hydrophobic vitamin E and hydrophilic vitamin B labeled with dual pH and glutathione-responsive
degradable linkages. Vitamin-based micelles (vitamicelles), formed by self-assembly in aqueous
solutions, were optimized based on their stability after encapsulation of doxorubicin (DOX). The
resulting vitamicelles have great potential as vehicles for anticancer drugs because they show excellent biocompatibility (>94% after 48 h of incubation) and rapid biodegradability (>90% after
2.5 h). Compared with free DOX, DOX-loaded vitamicelles showed a markedly enhanced anticancer effect as they released the drug rapidly and inhibited drug efflux out of cells efficiently. By
exploiting these advantages, this study not only provides a promising strategy for circumventing
existing challenges regarding the delivery of anticancer drugs but also extends the utility of current
DOX-induced chemotherapy.
Author(s)
고나래김도운김석영백찬기오승준이상주Apoorvi TyagiArun Pandian ChandrasekaranSuresh Ramakrishna
Issued Date
2021
Type
Article
Keyword
vitaminsnanomedicinesstimuli-responsive degradationchemotherapydoxorubicin
DOI
10.3390/ijms222011298
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9662
https://ulsan-primo.hosted.exlibrisgroup.com/primo-explore/fulldisplay?docid=TN_cdi_doaj_primary_oai_doaj_org_article_f38fa36f02a34b4796d2c5022b488d63&context=PC&vid=ULSAN&lang=ko_KR&search_scope=default_scope&adaptor=primo_central_multiple_fe&tab=default_tab&query=any,contains,Smart%20Vitamin%20Micelles%20as%20Cancer%20Nanomedicines%20for%20Enhanced%20Intracellular%20Delivery%20of%20Doxorubicin&offset=0&pcAvailability=true
Publisher
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Location
스위스
Language
한국어
ISSN
1422-0067
Citation Volume
22
Citation Start Page
11298
Citation End Page
11317
Appears in Collections:
Natural Science > Chemistry
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