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Listeria monocytogenes에 대한 선천 면역반응에서 DRG2의 역할 연구

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Abstract
The ability of macrophages to produce inflammatory cytokines plays a pivotal role in the innate immune response. Here we demonstrated that developmentally regulated GTP binding protein 2 (DRG2) −/− macrophages are intrinsically defective in migration and inflammatory cytokine production. DRG2-/- macrophages showed increased inhibitory phosphorylation of GSK3β and decreased transcriptional activity of NF-κB upon infection with Listeria monocytogenes. L. monocytogenes is a pathogen causing listeriosis that can be serious for individuals with impaired immune system. The innate immune response is critical for the control of early L. monocytogenes infection. Here, we report that DRG2 is a major regulator of innate immune response against L. monocytogenes infection. Using a DRG2−/− mouse, we determined that DRG2 deficiency decreased survival upon L. monocytogenes infection. Additionally, in DRG2 macrophage specific KO mice, compared to DRG2 fl/fl mice, decreased survival upon L. monocytogenes infection. Lastly, DRG2−/− macrophages showed increase in the inhibitory phosphorylation of GSK3β and decrease in the transcriptional activity of NF-κB upon L. monocytogenes infection. Our findings reveal a novel function of DRG2 in the cytokine production of immune cells and control of L. monocytogenes infection and host resistance.
Author(s)
이언화
Issued Date
2022
Awarded Date
2022-08
Type
dissertation
URI
https://oak.ulsan.ac.kr/handle/2021.oak/9833
http://ulsan.dcollection.net/common/orgView/200000635419
Alternative Author(s)
Unnhwa Lee
Affiliation
울산대학교
Department
일반대학원 생명과학과
Advisor
박정우
Degree
Doctor
Publisher
울산대학교 일반대학원 생명과학과
Language
eng
Rights
울산대학교 논문은 저작권에 의해 보호 받습니다.
Appears in Collections:
Life Science > 2. Theses (Ph.D)
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