피부노출 경로를 통한 비스페놀 F의 광범위한 독성학적 영향 연구

Abstract

Among life chemicals, Bisphenol F(BPF) is used as a substitute for Bisphenol A(BPA) in food containers, water supply pipes, and thermal papers for receipts, and is actually detected in drinking water and human urine samples in Korea. However, due to limited research on the toxicity information on Bisphenol F, it is difficult to prepare appropriate guidelines for use and social anxiety is amplifying. In recent studies, Bisphenol F has also been pointed out as an endocrine disruptor, and related risks have been revealed through research. However, most of these studies focused on human exposure to BPF through direct ingestion or inhalation, and studies evaluating the toxicological effects of BPF mainly through skin contact are lacking. Therefore, in this study, we conducted comprehensive toxicity tests focusing on dermal exposure. Through in vitro application, the degree of absorption into the skin and the permeation pattern were evaluated. a single-dose dermal toxicity test, 14-day repeat dermal dose-range finding study, 28-day repeat dermal toxicity test were performed to identify the no observed adverse effect level (NOAEL) and target organs during skin exposure. Skin irritation test and eye irritation test were performed to determine local irritation upon skin exposure, and a skin sensitization test was performed to evaluate delayed hypersensitivity reactions following skin contact.

Results showed that BPF was absorbed through the skin at a high rate, as indicated by the amount of BPF remaining in the epidermis or dermis, compared with other bisphenol analogs. BPF penetrated into the subcutaneous layer at a very fast rate. No toxicological changes or local irritation were observed after skin exposure to BPF. However, BPF induced a strong sensitization similar to that of positive (HCA). the findings of this study demonstrated the significant implications of skin exposure through the results of high rates of skin penetration and skin absorption of BPF, and the result of extensive toxicological evaluation of skin exposure to BPF confirmed BPF inducing skin sensitization.